Most Dangerous Game Show is the seventy-eighth episode of Ben 10: Omniverse.
- Elena Validus, Eunice, Jennifer Nocturne, Sunny, Myaxx and Antonio make their Omniverse debuts.
- The negative afflictions on Elena Validus, Charmcaster, and Jennifer Nocturne are shown to have been reversed.
- Ester and Ben end their relationship on good terms but are still friends.
- Ester starts going out with Antonio.
- Kai and Ben become a couple. They share their second kiss.
- Ben Tennyson
- Rook Blonko
- Kai Green
- Looma Red Wind
- Elena Validus (first re-appearance)
- Jennifer Nocturne
- Queen Voratia Rumbletum
- Rook Shar
- Antonio (first re-appearance)
- Eunice (first re-appearance)
- Sunny (first re-appearance)
- Julie Yamamoto
- Drew Saturday
- Isosceles Right Triangle Vreedle
- Ma Vreedle
- Nyancy Chan
- Gwen Tennyson
- Sandra Tennyson
- Vera Tennyson
- Lucy Mann
- Helena Xagliv
- Helen Wheels
- Max Tennyson
- Magister Patelliday
- Magister Arnux
- Molly Gunther
- Natalie Alvarez
- Madison's Father
- Echo Echo (x2)
- Rayonna is eliminated and poofed away, but in the next group shot she is there again in place of Rook Shar.
- Lucy is in the group shot in the Null Void even when she shouldn't be there.
- Professor Xagliv and Fistina are in the group shot when Ben and the girls get out of the Null Void even though Xagliv was taken out from competing in the contest at the start (thus was not in the Null Void) and Fistina was never in the episode at any point. In addition, she is wearing her villainous uniform instead of her Plumbers outfit.
- The title is a play of the short story "The Most Dangerous Game", written by Richard Connell in 1924.
- One of the games that the contestants competed in involved jumping through holes in moving walls. Which is a reference to the game show Hole in the Wall.
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