|This article belongs to the Classic Continuity|
The Nuclear Fusion Grenade first appeared in the episode War of the Worlds: Part 2.
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In The Enemy of My Enemy, Octagon Vreedle used it against Ultimate Kevin, but because of his lack of intelligence, he forgot to consider the fact that it had the power to destroy the entire Plumbers' Academy space station along with everyone in it. Ultimate Echo Echo took the bomb out into space away from the academy and let it explode there, not harming anyone.