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In For a Few Brains More, Albedo built a second one at Billions Tower, where he absorbed Azmuth's brain. However, Ben as Bloxx reverted the process. It was later used to put Azmuth's intelligence back into him.
Ben 10: Omniverse
- The original Cerebral Vortex, once the lid was open, looked similar to the original Ultimatrix.
- The Cerebral Vortex is named after the Cerebral Cortex, a part of mammalian brains.